Steroids, if used following kidney transplantation would cause which of the following side effects?
A. Alopecia
B. Increase Cholesterol Level
C. Orthostatic Hypotension
D. Increase Blood Glucose Level
Correct Answer: D. Increased Blood Glucose Level
In the past, people with kidney transplants usually have taken steroids (such as prednisone) as one of their immunosuppressive medications to prevent rejection. But steroids may cause weight gain, diabetes, high blood pressure, heart and blood vessel disease (cardiovascular disease), osteoporosis, and other problems.
Option A: Alopecia is a complication of organ transplantation and has been observed with increasing frequency in pancreas and kidney transplant recipients at UMMS. Several patients have presented with alopecia totalis and no obvious etiology. Many of the drugs commonly used after transplant have been reported to cause alopecia; however, it was not known if one of the medications used was a primary cause to this disturbing problem.
Option B: Because hyperlipidemia occurs in 60–80% of kidney transplant recipients, findings might be of clinical value for the future improvement of kidney transplantation outcome. Although the underlying mechanisms of their findings are not clear, high serum cholesterol levels may increase the risks of cardiovascular disease and impair renal function, which may influence graft and patient survivals.
Option C: Orthostatic hypotension is common after kidney-pancreas transplant. It is unrelated to preexisting autonomic neuropathy or posttransplant polyuria in most patients. This complication requires further study.
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