Pneumonia Q 32 - Gyan Darpan : Learning Portal
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Wednesday 20 April 2022

Pneumonia Q 32

The client experiencing eighth cranial nerve damage will most likely report which of the following symptoms?
     A. Vertigo
     B. Facial paralysis
     C. Impaired vision
     D. Difficulty swallowing

Correct Answer: A. Vertigo

The eighth cranial nerve is the vestibulocochlear nerve, which is responsible for hearing and equilibrium. Streptomycin can damage this nerve. Ototoxicity and vestibular impairment are often thought to be the hallmark of streptomycin toxicity. In extreme cases, deafness may occur due to ototoxicity, thus caution must be exercised when combining streptomycin with other potentially ototoxic drugs. Vestibular impairment usually manifests during the course of treatment and is typically permanent.

Option B: Isoniazid can cause pyridoxine deficiency that may lead to peripheral neuropathy in patients. The patient can supplement vitamin B6 to prevent this from happening. Neuropathy symptoms are usually sensory which include numbness, tingling, burning sensation in all the extremities. Rarely seen are central features like ataxia, nystagmus.
Option C: The manifestation of EMB-induced optic neuropathy appears to be from EMB’s chelation of copper. A study with 60 patients undergoing treatment with ethambutol monitored their serum copper levels. Statistical analysis confirmed there was a significant change in copper concentration, supporting the copper chelation effect by EMB.
Option D: Aminoglycoside-induced nephrotoxicity is reversible when stopping the medication. Renal toxicity depends on the patient if any underlying renal disease is present, and on the dose of the medication being administered. Renal insufficiency is avoidable in most patients.

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