Cancer can cause changes in what component of Virchow’s triad?
A. Blood coagulability
B. Vessel walls
C. Blood flow
D. Blood viscosity
Correct Answer: A. Blood coagulability
Charles Emile Troisier later recognized the further association of other abdominal cancers as well as testicular cancer with the presence of Virchow’s node. Virchow sought to explain the causation of pulmonary thromboembolism and theorized that pulmonary arterial embolus arises from peripheral/distant thrombosis.
Option B: Damage to the endothelial wall of a vessel alters the dynamics of blood flow. Endothelial disturbance can result from insults such as smoking, chronically elevated blood pressure, and atherosclerotic disease secondary to hyperlipidemia. When an insult to the wall occurs, flow disruption or “turbulence” occurs.
Option C: The thinking is that as blood flow slows through vascular beds, flow reduces, and the natural anticoagulant properties from interaction with surface proteins are affected, resulting in thrombi production.
Option D: Hypercoagulability can occur due to a variety of clinical statuses such as pregnancy, use of oral contraceptive medications, cancer, chemotherapy drugs, and inherited thrombophilias.
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