Rosemary has been taking glargine (Lantus) to treat her condition. One of the benefits of glargine (Lantus) insulin is its ability to:
A. Release insulin rapidly throughout the day to help control basal glucose.
B. Release insulin evenly throughout the day and control basal glucose levels.
C. Simplify the dosing and better control blood glucose levels during the day.
D. Cause hypoglycemia with other manifestations of other adverse reactions.
Correct Answer: B. Release insulin evenly throughout the day and control basal glucose levels.
Glargine (Lantus) insulin is designed to release insulin evenly throughout the day and control basal glucose levels. Insulin glargine is long-acting insulin injected once daily and provides a basal level of insulin throughout the day.
Option A: Insulin glargine has an onset of action of 1.5 to 2 hours. It has a long duration of action up to 24 hours due to modifications of amino acids, including Asn to Gly at position 21 of the A chain and the addition of two Arg residues and positions 31 and 32 of the B chain.
Option C: Regimens often combine it with rapid-acting insulin to obtain optimal glycemic control. Decisions of when to administer insulin glargine are dependent on the patient’s schedule and the resultant effects that the insulin has on the particular patient’s blood glucose levels.
Option D: The most common adverse effect of insulin glargine is hypoglycemia. Special attention is necessary for insulin usage in fasting patients, those who have recently changed their diets or have had recent activity changes such as beginning a workout program.
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