Rhea has malignant lymphoma. As part of her chemotherapy, the physician prescribes chlorambucil (Leukeran), 10 mg by mouth daily. When caring for the client, the nurse teaches her about adverse reactions to chlorambucil, such as alopecia. How soon after the first administration of chlorambucil might this reaction occur?
A. Immediately
B. 1 week
C. 2 to 3 weeks
D. 1 month
Correct Answer: C. 2 to 3 weeks
Chlorambucil-induced alopecia occurs 2 to 3 weeks after therapy begins. The medication causes structural damage to the scalp hairs resulting in reduced hair growth and complete hair loss (alopecia).
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