In which of the following diseases would bone marrow transplantation not be indicated in a newly diagnosed client?
A. Severe aplastic anemia
B. Severe combined immunodeficiency
C. Acute lymphocytic leukemia
D. Chronic myeloid leukemia
Correct Answer: C. Acute lymphocytic leukemia
Option C: For the first episode of acute lymphocytic leukemia, conventional therapy is superior to bone marrow transplantation. Treatment is usually long-term chemotherapy and is composed of 3 phases (induction, consolidation, and maintenance).
Options A and B: In severe combined immunodeficiency and in severe aplastic anemia, bone marrow transplantation has been employed to replace abnormal stem cells with healthy cells from the donor’s marrow.
Option D: In myeloid leukemia, bone marrow transplantation is done after chemotherapy to infuse healthy marrow and to replace marrow stem cells ablated during chemotherapy.
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