A female client is receiving methotrexate (Mexate), 12 g/m2 I.V., to treat osteogenic carcinoma. During methotrexate therapy, the nurse expects the client to receive which other drug to protect normal cells?
A. Tabloid (thioguanine)
B. Cytosar-U (cytarabine)
C. Wellcovorin (leucovorin or citrovorum factor or folinic acid)
D. Benemid (probenecid)
Correct Answer: C. Wellcovorin (leucovorin or citrovorum factor or folinic acid)
Option C: Leucovorin is administered with methotrexate to protect normal cells, which methotrexate could destroy if given alone.
Options A and B: Cytarabine and thioguanine aren’t used to treat osteogenic carcinoma.
Option D: Probenecid should be avoided in clients receiving methotrexate because it reduces renal elimination of methotrexate, increasing the risk of methotrexate toxicity.
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