A male client is receiving the cell cycle–nonspecific alkylating agent Thioplex (thiotepa), 60 mg weekly for 4 weeks by bladder instillation as part of a chemotherapeutic regimen to treat bladder cancer. The client asks the nurse how the drug works. How does thiotepa exert its therapeutic effects?
A. It interferes with deoxyribonucleic acid (DNA) replication only
B. It interferes with ribonucleic acid (RNA) transcription only
C. It interferes with DNA replication and RNA transcription
D. It destroys the cell membrane, causing lysis
Correct Answer: C. It interferes with DNA replication and RNA transcription.
Option C: Thiotepa is an alkylating agent that works by crosslinking DNA strands by reacting with phosphate groups to stop protein synthesis, RNA, and DNA.
Options A, B, and D: Thiotepa interferes with DNA replication and RNA transcription. It doesn’t destroy the cell membrane.
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